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Activated Protein C Mediates Novel Lung Endothelial Barrier Enhancement - Role Of Sphingosine 1-Phosphate Receptor Transactivation

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 17 (2005): 17286-17293

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academic.microsoft.com pubmed.ncbi.nlm.nih.gov

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Increased endothelial cell (EC) permeability is central to the pathophysiology of inflammatory syndromes such as sepsis and acute lung injury (ALI). Activated protein C (APC), a serine protease critically involved in the regulation of coagulation and inflammatory processes, improves sepsis survival through an unknown mechanism. We hypothe...更多

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