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Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

JOURNAL OF CLINICAL INVESTIGATION, no. 3 (2001): 351-361

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academic.microsoft.com pubmed.ncbi.nlm.nih.gov

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Abstract

Large granular lymphocyte (LGL) leukemia is characterized by the expansion of antigen-activated cytocoxic T lymphocytes. These leukemic cells are resistant to Fas-mediated apoptosis despite expressing high levels of Fas. We found that leukemic LGL from 19 patients displayed high levels of activated STAT3. Treatment of leukemic LGL with th...More

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