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Kinetic analysis of amyloid formation in the presence of heparan sulfate: faster unfolding and change of pathway.

The Journal of biological chemistry, no. 43 (2009): 29921-29934

Cited by: 65|Views5
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Abstract

A number of human diseases are associated with the conversion of proteins from their native state into well defined fibrillar aggregates, depositing in the extracellular space and generally termed amyloid fibrils. Heparan sulfate (HS), a glycosaminoglycan normally present in the extracellular matrix, has been found to be universally assoc...More

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