Marquages Par [14C] Et [13C] De La N‐(2‐diéthylaminoéthyl)‐4‐iodobenzamide Et De La N‐(3‐diméthylaminoprophyl)‐4‐iodobenzamide, Traceurs Du Mélanome

N-(2-dielhytaminoethyl)-4-iodobenzamide (I) and N-(3-dimethylaminopropyl)-4-iodobenzamide (II), recently developed in our laboratory, are promising agents for metastatic melanoma detection in nuclear medicine. In order to study their ''in vivo'' metabolism, we labelled them with carbon-14 and carbon-13 on two sites :on the carbonyl group (Ia, IIa), and on the dialkylaminoalkyl moiety (Ib, IIb). The overall yields calculated from sodium [C-14] or [C-13] cyanide used as precursor are in the range of 55 % for Ia, IIa, IIb, and 21 % for Ib.