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The Long Signal Peptide Isoform And Its Alternative Processing Direct The Intracellular Trafficking Of Interleukin-15

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 39 (2000): 30653-30659

Cited: 97|Views26

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pubmed.ncbi.nlm.nih.gov academic.microsoft.com

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signal peptide

Abstract

Two isoforms of interleukin (IL)-15 exist: one with a short and another with a long signal peptide (LSP). Experiments using combinations of the LSP and mature proteins IL-2, IL-15, and green fluorescent protein revealed complex pathways of intracellular trafficking. In one pathway, the LSP was unprocessed, and IL-15 was not glycosylated, ...More

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