Hiv-1 Tat Induces Monocyte Chemoattractant Protein-1-Mediated Monocyte Transmigration Across A Model Of The Human Blood-Brain Barrier And Up-Regulates Ccr5 Expression On Human Monocytes

AIDS dementia is characterized by neuronal loss in association with synaptic damage. A central predictor for clinical onset of these symptoms is the infiltration of monocytes and macrophages into CNS parenchyma, Chronic HIV-1 infection of monocytes also allows these cells to serve as reservoirs for persistent viral infection. Using a cocu...更多