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Polyvinyl Derivatives as Novel Interactive Polymers for Controlled Gene Delivery to Muscle

Pharmaceutical research, no. 5 (1996): 701-709

Cited by: 264|Views6
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Abstract

Purpose. DNA plasmids (pDNA) can be taken up by and expressed in striated muscle after direct intramuscular injection. We have developed interactive polymeric gene delivery systems that increase pDNA bioavailability to muscle cells by both protecting pDNA from nucleases and controlling the dispersion and retention of pDNA in muscle tissue...More

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