Influence of GST gene polymorphisms on busulfan pharmacokinetics in children.
BONE MARROW TRANSPLANTATION, no. 2.0 (2010): 261-267
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Abstract
Busulfan (BU) is a key compound in conditioning myeloablative regimens for children undergoing hematopoietic stem cell transplantation (HSCT). There are wide interindividual differences in BU pharmacokinetics, which increase the risk of veno-occlusive disease, graft rejection and disease relapse. As BU is mainly metabolized by glutathione...More
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