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Nrdpl/Flrf Is A Ubiquitin Ligase Promoting Ubiquitination And Degradation Of The Epidermal Growth Factor Receptor Family Member, Erbb3

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, no. 23 (2002): 14843-14848

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non-programmaticubiquitinubiquitin ligasecell growthproteinsMore(6+)

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The epidermal growth factor receptor (EGFR/ErbB) family of receptor tyrosine kinases plays fundamental roles in the regulation of cell survival, proliferation, and differentiation. Here, we present evidence that ErbB3 is degraded by proteasomes, and that Nrdp1 (referred to as FLRF in mice) associates with ErbB3 and stimulates its ubiquiti...More

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Xiao-Bo Qiu (邱小波)

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Alfred L Goldberg

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