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Structural and functional analysis of hepatitis C virus strain JFH1 polymerase.

JOURNAL OF VIROLOGY, no. 22 (2009): 11926-11939

Cited by: 82|Views19
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Abstract

The hepatitis C virus (HCV) isolate JFH1 represents the only cloned wild-type sequence capable of efficient replication in cell culture, as well as in chimpanzees. Previous reports have pointed to the viral polymerase NS5B as a major determinant for efficient replication of this isolate. To understand the underlying mechanisms, we express...More

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