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Dominant-Negative C/Ebp Disrupts Mitotic Clonal Expansion And Differentiation Of 3t3-L1 Preadipocytes

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, no. 1 (2004): 43-47

Cited: 131|Views24
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Abstract

Hormonal induction of growth-arrested 3T3-L1 preadipocytes rapidly activates expression of CCAAT/enhancer-binding protein (C/EBP) beta. Acquisition of DNA-binding activity by C/EBPbeta, however, is delayed until the cells synchronously enter the S phase of mitotic clonal expansion (MCE). After MCE, C/EBPbeta activates expression of C/EBPa...More

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