The Orphan G Protein-Coupled Receptor Gpr40 Is Activated By Medium And Long Chain Fatty Acids

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 13 (2003): 11303-11311

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GPR40 is a member of a subfamily of homologous G protein-coupled receptors that include GPR41 and GPR43 and that have no current function or ligand ascribed. Ligand fishing experiments in HEK293 cells expressing human GPR40 revealed that a range of saturated and unsaturated carboxylic acids with carbon chain lengths greater than six were ...更多

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