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Increase in AP-1 transcription factor DNA binding activity by valproic acid.
Neuropsychopharmacology, no. 3 (1997): 238-245
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Valproic acid (VPA), a simple branched fatty acid anticonvulsant, has been demonstrated to have clinical efficacy in the treatment of manic-depressive illness (Bowden et al., 1994), but the mechanism(s) by which VPA produces its therapeutic effects remain to be elucidated. VPA's clinical antimanic action require a lag period for onset and...更多
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