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Loss Of Mitogen-Activated Protein Kinase Kinase Kinase 4 (Mekk4) Results In Enhanced Apoptosis And Defective Neural Tube Development

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, no. 10 (2005): 3846-3851

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Neural tube defects (NTDs) are prevalent human birth defects. Mitogen-activated protein kinases (MAPKs), such as c-Jun N-terminal kinase (JNK), are implicated in facilitating neural tube closure, yet upstream regulators remain to be identified. Here, we show that MAP kinase kinase kinase 4 (MEKK4) is strongly expressed in the developing n...更多

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