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The involvement of the NMDA receptor D-serine/glycine site in the pathophysiology and treatment of schizophrenia.

Neuroscience & Biobehavioral Reviews, no. 3 (2010): 351-372

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Hypofunction of the N-methyl-d-aspartate receptor (NMDAR) has been implicated in the pathophysiology of schizophrenia. The NMDAR contains a d-serine/glycine site on the NR1 subunit that may be a promising therapeutic target for psychiatric illness. This review outlines the complex regulation of endogenous NMDAR d-serine/glycine site agoni...更多

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