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Cisplatin Inhibits Chromatin Remodeling, Transcription Factor-Binding, And Transcription From The Mouse Mammary-Tumor Virus Promoter In-Vivo

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, no. 6 (1995): 2076-2080

Cited: 60|Views22
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Abstract

The anticancer drug cis-diamminedichloroplatinum(II) (cisplatin) covalently modifies DNA, and these lesions are thought to lead to cell death by inhibiting DNA and RNA synthesis, By using in vivo analysis techniques, we have investigated the influence of cisplatin on hormone-induced transcription from the mouse mammary tumor virus (MMTV) ...More

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