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Nickel Ions Inhibit Histone Demethylase Jmjd1a And Dna Repair Enzyme Abh2 By Replacing The Ferrous Iron In The Catalytic Centers

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 10 (2010): 7374-7383

Cited: 107|Views21
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Abstract

Iron- and 2-oxoglutarate-dependent dioxygenases are a diverse family of non-heme iron enzymes that catalyze various important oxidations in cells. A key structural motif of these dioxygenases is a facial triad of 2-histidines-1-carboxylate that coordinates the Fe(II) at the catalytic site. Using histone demethylase JMJD1A and DNA repair e...More

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