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Attenuated, replication-competent herpes simplex virus type 1 mutant G207: safety evaluation in mice.

JOURNAL OF VIROLOGY, no. 8 (2000): 3832-3841

Cited: 107|Views23
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Abstract

Herpes simplex virus type 1 (HSV-1) mutants that are attenuated for neurovirulence are being used for the treatment of cancer. We have examined the safety of G207, a multimutated replication-competent HSV-1 vector, in mice. BALB/c mice inoculated intracerebrally or intracerebroventricularly with 10(7) PFU of G207 survived for over 20 week...More

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