Effects of Methylphenidate Treatment in Children With Mental Retardation and ADHD: Individual Variation in Medication Response

Deborah A. Pearson,David M. Lane,Cynthia W. Santos,Charles D. Casat,Susan W. Jerger,Katherine A. Loveland,Faria Laura P,Mansour Rosleen,Jill A. Henderson,Christa D. Payne,Roache John D,David Lachar,Cleveland Lynne A

Journal of the American Academy of Child & Adolescent Psychiatry（2004）

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摘要

Conclusions At the 0.60-mg/kg MPH dose, more children showed substantial cognitive and behavioral gains than those who showed substantial declines in a ratio of more than 5:1. However, it may be prudent to assess cognitive change as well as behavioral effects because improvements in the former do not necessarily forecast improvements in the latter in children with attention-deficit/hyperactivity disorder and mental retardation.

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methylphenidate,mental retardation,attention-deficit/hyperactivity disorder,children,behavior,cognition

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