Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination.

MOLECULAR AND CELLULAR BIOLOGY, no. 19 (2005): 8656-8668

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In this study we find that the function of BRCA1 inhibits the microtubule nucleation function of centrosomes. In particular, cells in early S phase have quiescent centrosomes due to BRCA1 activity, which inhibits the association of gamma-tubulin with centrosomes. We find that modification of either of two specific lysine residues (Lys-48 ...更多

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