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Thymus - A Direct Target Tissue In Graft-Versus-Host Reaction After Allogeneic Bone-Marrow Transplantation That Results In Abrogation Of Induction Of Self-Tolerance

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, no. 16 (1990): 6301-6305

Cited: 100|Views28
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Abstract

Graft-versus-host reaction (GVHR) following allogeneic bone marrow (BM) transplantation was investigated by analyzing expression of antigen receptors on T cells specific for recipient antigens. GVHR chimeras were prepared by transplanting mixtures of splenic T cells and T-cell-depleted BM cells from B10 (I-E-, Mls-1b) or B10.AQR (I-E+, Ml...More

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