Electron microscopy of high pressure frozen samples: bridging the gap between cellular ultrastructure and atomic resolution.

Histochemistry and cell biology, no. 5 (2008): 877-889

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Transmission electron microscopy has provided most of what is known about the ultrastructural organization of tissues, cells, and organelles. Due to tremendous advances in crystallography and magnetic resonance imaging, almost any protein can now be modeled at atomic resolution. To fully understand the workings of biological "nanomachines...更多

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