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Ovine adenovirus vectors overcome preexisting humoral immunity against human adenoviruses in vivo.

JOURNAL OF VIROLOGY, no. 8 (1999): 6930-6936

Cited by: 106|Views5
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Abstract

Recombinant human adenoviruses (hAd) have become widely used as tools to achieve efficient gene transfer. However, successful application of hAd-derived vectors in clinical trials is limited due to immunological and potential safety problems inherent in their human origin. In this study, we describe a recombinant ovine adenovirus (OAV) as...More

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