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Erk-Mediated Regulation Of Leukotriene Biosynthesis By Androgens: A Molecular Basis For Gender Differences In Inflammation And Asthma

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, no. 50 (2008): 19881-19886

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5-Lipoxygenase initiates the biosynthesis of leukotrienes, lipid mediators involved in normal host defense and in inflammatory and allergic disorders. Despite an obvious gender bias in leukotriene-related diseases (e.g., asthma), gender aspects have been neglected in studies on leukotrienes and 5-lipoxygenase. Here, we show that leukotrie...更多

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