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Toward an integrated structural model of the 26S proteasome.
Molecular & cellular proteomics : MCP, no. 8 (2010): 1666-1677
The 26S proteasome is the end point of the ubiquitin-proteasome pathway and degrades ubiquitylated substrates. It is composed of the 20S core particle (CP), where degradation occurs, and the 19S regulatory particle (RP), which ensures substrate specificity of degradation. Whereas the CP is resolved to atomic resolution, the architecture o...More
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