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The Human Mdm2 Oncoprotein Increases The Transcriptional Activity And The Protein Level Of The P53 Homolog P63

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 4 (2002): 2674-2681

Cited: 73|Views24
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Abstract

Genetic alteration of the p53 tumor suppressor gene, which monitors DNA damage and operates cell cycle checkpoints, is a major factor in the development of human malignancies. The p53 protein belongs to a family that also includes two structurally related proteins, p63 and p73. Although all three proteins share similar transcriptional fun...More

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