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A Centralized Gene-Based Hiv-1 Vaccine Elicits Broad Cross-Clade Cellular Immune Responses In Rhesus Monkeys
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, no. 30 (2008): 10489-10494
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one of the major challenges that must be met in developing an HIV-1 vaccine is devising a strategy to generate cellular immunity with sufficient breadth to deal with the extraordinary genetic diversity of the virus. Amino acids in the envelopes of viruses from the same clade can differ by >15%, and those from different clades can differ b...更多
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