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Sequential regulation of the small GTPase Rap1 in human platelets.

MOLECULAR AND CELLULAR BIOLOGY, no. 3 (2000): 779-785

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Rap1, a small GTPase of the Ras family, is ubiquitously expressed and particularly abundant in platelets. Previously we have shown that Rap1 is rapidly activated after stimulation of human platelets with alpha-thrombin. For this activation, a phospholipase C-mediated increase in intracellular calcium is necessary and sufficient. Here we s...更多

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