Vpu-mediated tetherin antagonism of ongoing HIV-1 infection in CD4+ T-cells is not directly related to the extent of tetherin cell surface downmodulation

Björn D. Kuhl,Richard D. Sloan,Daniel A. Donahue,Chen Liang,Mark A. Wainberg

Virology（2011）

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摘要

Tetherin is a host cell restriction factor that acts against HIV-1 and other enveloped viruses. The antiviral activity of tetherin is antagonized by the HIV-1 protein Vpu, that downregulates tetherin from the cell surface.

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关键词

HIV-1,Tetherin,Cell-to-cell spread,Virus release,Vpu,Tetherin,CD4+ T-cell

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