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Bace1 Cytoplasmic Domain Interacts With The Copper Chaperone For Superoxide Dismutase-1 And Binds Copper
JOURNAL OF BIOLOGICAL CHEMISTRY, no. 18 (2005): 17930-17937
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The amyloidogenic pathway leading to the production and deposition of A beta peptides, major constituents of Alzheimer disease senile plaques, is linked to neuronal metal homeostasis. The amyloid precursor protein binds copper and zinc in its extracellular domain, and the A beta peptides also bind copper, zinc, and iron. The first step in...更多
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