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Peptide specificity of thymic selection of CD4+CD25+ T cells.
Journal of immunology (Baltimore, Md. : 1950), no. 2 (2002): 613-620
The CD4(+)CD25(+) regulatory T cells can be found in the thymus, but their need to undergo positive and negative selection has been questioned. Instead, it has been hypothesized that CD4(+)CD25(+) cells mature following TCR binding to MHC backbone, to low abundant MHC/peptide complexes, or to class II MHC loaded with peripheral autoantige...More
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