Activating Mutation Of D835 Within The Activation Loop Of Flt3 In Human Hematologic Malignancies

BLOOD, no. 8 (2001): 2434-2439

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Mutations of receptor tyrosine kinases are implicated in the constitutive activation and development of human malignancy. An internal tandem duplication (ITD) of the juxtamembrane (JM) domain-coding sequence of the FLT3 gene (FLT3/ITD) is found in 20% of patients with acute myeloid leukemia (AML) and is strongly associated with leukocytos...更多

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