Two polymorphic variants of wild-type p53 differ biochemically and biologically.

The wild-type p53 protein exhibits a common polymorphism at amino acid 72? resulting in either a proline residue (p53(Pro)) or an arginine residue (p53(Arg)) at this position. Despite the difference that this change makes in the primary structure of the protein resulting in a difference in migration during sodium dodecyl sulfate-polyacryl...更多