Novel inhibitors of the hepatitis C virus NS3 proteinase.

Frank Bennett,Yi-Tsung Liu,Anil K Saksena,Ashok Arasappan,Nancy Butkiewicz,Bimalendu Dasmahapatra,John S Pichardo,F George Njoroge,Naginbhai M Patel,Yuhua Huang,Xiaozheng Yang

Bioorganic & Medicinal Chemistry Letters（2005）

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摘要

The hepatitis C virus proteinase inhibitor 4-methyl-1-(phenylmethyl)-2,6-pyridinedione 1 undergoes a novel autoxidation process, on silica gel, leading to the dimer 2 as the major product, a relatively more potent inhibitor of the enzyme.

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关键词

Hepatitis,Proteinase

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