Prediction of Clearance in Children Using a Combined Physiology-based and Enzyme Ontogeny Approach

msra（2002）

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摘要

UGT1A6 (60%), sulfonation (30%), CYP2E1 (5%), renal (5%) CYP1A2 (65%), CYP3A4 (32%), renal (3%) CYP3A4 (90%), Renal (10%)

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