Synthesis and anti-inflammatory activity of a series of N-substituted naproxen glycolamides: nitric oxide-donor naproxen prodrugs.

Ramani R Ranatunge,Michael E Augustyniak,Vijay Dhawan,James L Ellis,David S Garvey,David R Janero,L Gordon Letts,Stewart K Richardson,Mathew J Shumway,A Mark Trocha,Delano V Young,Irina S Zemtseva

Bioorganic & Medicinal Chemistry（2006）

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摘要

The synthesis of a series of NO-donating N-substituted glycolamides of naproxen and their anti-inflammatory activity, naproxen release, potential for NO formation, and gastrointestinal safety are reported.

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关键词

Non-steroidal anti-inflammatory drug (NSAID),Nitric oxide,Naproxen,CINOD,Anit-inflammatory,Cyclo-oxygenase

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