Proline-directed random-coil chemical shift values as a tool for the NMR assignment of the tau phosphorylation sites (vol 5, pg 73, 2004)
CHEMBIOCHEM(2004)
摘要
NMR spectroscopy of the full-length neuronal Tau protein has proved to be difficult due to the length of the protein and the unfavorable amino acid composition. We show that the random-coil chemical shift values and their dependence on the presence of a proline residue in the (i + 1) position can successfully be exploited to assign all proline-directed phosphorylation sites. This is a first step toward the study of the phosphorylation of Tau by NMR spectroscopy.
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关键词
NMR spectroscopy,phosphorylation,proline,protein structures,Tau protein
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