Tyrosine kinase inhibitors for the treatment of acute myeloid leukemia: delineation of anti-leukemic mechanisms of action.

Elodie Lainey,Sylvain Thépot,Cyrielle Bouteloup,Marie Sébert,Lionel Adès,Maximilien Tailler,Claude Gardin,Stéphane de Botton,André Baruchel,Pierre Fenaux,Guido Kroemer,Simone Boehrer

Biochemical Pharmacology（2011）

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摘要

Here we describe the results of a side-by-side comparison of the anti-leukemic efficacy of four different TKI (erlotinib, lapatinib, sorafenib and dasatinib) in MDS and AML.

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关键词

Apoptosis,Differentiation,Epidermal growth factor receptor,Tyrosine kinases,Erlotinib,Lapatinib

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