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Kinetic measurements of DNA hybridization on an oligonucleotide-immobilized 27-MHz quartz crystal microbalance.

ANALYTICAL CHEMISTRY, no. 7 (1998): 1288-1296

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A highly sensitive 27-MHz quartz-crystal microbalance, on which a 10-30-mer oligonucleotide was immobilized as a probe molecule, was employed to detect hybridization of complementary oligonucleotides in aqueous solution, From frequency decreases (mass increases due to the hybridization) with passage of time, kinetic parameters such as ass...更多

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