Sliding Clamp–DNA Interactions Are Required for Viability and Contribute to DNA Polymerase Management in Escherichia coli

Journal of Molecular Biology, pp. 74-91, 2009.

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Abstract:

Sliding clamp proteins topologically encircle DNA and play vital roles in coordinating the actions of various DNA replication, repair, and damage tolerance proteins. At least three distinct surfaces of the Escherichia coli β clamp interact physically with the DNA that it topologically encircles. We utilized mutant β clamp proteins bearing...More

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