P.7.a.008 Treatment Compliance in Children and Adolescents Initiated on ADHD Medication in Clinical Practice (COMPLY)

Studies investigating the association between antipsychotic use and the risk of cerebrovascular accident (CVA) showed inconsistent results.Conduct a systematic review and meta-analysis to evaluate whether use of antipsychotics is associated with increased risk of CVA.Major electronic databases were searched from 1970 to October 2016 for observational studies investigating the risk of CVA among users of antipsychotics. Pooled estimates of odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by random effects meta-analysis.Of 1171 citations identified, 10 studies were considered eligible. Significant increase in risk of CVA was associated with first-generation antipsychotics (OR 1.49; 95% CI 1.24–1.77) but not with second-generation antipsychotics (OR 1.31; 95% CI 0.74–2.30). Use of any antipsychotics in patients with dementia was associated with a low risk of CVA (OR 1.17; 95% CI 1.08–1.26).The available evidence suggests use of with first-generation antipsychotics as opposed to second-generation antipsychotics significantly increased the risk of CVA.