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SAR studies of non-zinc-chelating MMP-13 inhibitors: Improving selectivity and metabolic stability

Donghong Amy Gao,Zhaoming Xiong,Alexander Heim-Riether,Laura Amodeo,E. Michael August,Xianhua Cao,Leonard Ciccarelli,Brandon K. Collins,Kyle Harrington,Kathleen Haverty,Melissa Hill-Drzewi,Xiang Li,Shuang Liang,Steluta Mariana Margarit,Neil Moss,Nelamangala Nagaraja,John Proudfoot,Rene Roman,Sabine Schlyer,Lana Smith Keenan,Steven Taylor,Bernd Wellenzohn,Dieter Wiedenmayer,Jun Li,Neil A. Farrow

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要
SAR studies to improve the selectivity and metabolic stability of a class of recently discovered non-Zn-chelating MMP-13 inhibitors are reported.
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关键词
MMP-13,Non-Zn-chelating inhibitor,SAR,Selectivity,Metabolic stability
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