Anti-prostate specific membrane antigen designer T cells for prostate cancer therapy

PROSTATE, pp. 12-25, 2004.

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Abstract:

BACKGROUND. Designer T cells are T lymphocytes engineered toward specific antibody-type membrane antigens through chimeric immunoglobulin-T-cell receptor (IgTCR) genes that have been used for adoptive cellular immunotherapy. We have extended this approach to prostate specific membrane antigen (PSMA) as a means to attack prostate cancer. M...More

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