The proapoptotic activities of Bax and Bak limit the size of the neural stem cell pool.

JOURNAL OF NEUROSCIENCE, no. 35 (2003): 11112-11119

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The proapoptotic Bcl-2 family members Bak and Bax play central and redundant roles in the regulation of apoptosis. In this study, we investigated the effect of loss of Bax and Bak in the CNS. The adult bax(-/-) bak(-/-) mice display masses of densely staining cells in the proliferative zones of the brain. These cells are shown to be a mix...更多

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