Prediction of drug-induced liver injury in humans by using in vitro methods: the case of ximelagatran.

Kerstin Kenne,Inger Skanberg,Bjorn Glinghammar,Alain Berson,Dominique Pessayre,Jean-Pierre Flinois,Philippe Beaune,Irene Edebert,Cecilia Diaz Pohl,Stefan Carlsson,Tommy B Andersson

Toxicology in Vitro（2008）

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摘要

Objective: To investigate the possible mechanisms underlying the liver enzyme elevations seen during clinical studies of long-term treatment (>35 days) with ximelagatran, and investigate the usefulness of pre-clinical in vitro systems to predict drug-induced liver effects.

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ATP,ALT,AST,Cmax,DMSO,EC50,EDTA,HPLC,LC/MS,CYP,DILI,FXR,FRET,GSH,H2DCF-DA,IC50,LBD,LXR,MMP,MPT,NAD,NADPH,PBS,PI,PPAR,PXR,RCR,ROS,SDS,T3,TBHP,TCA,TBT,TNF-α,VTE,TRβ

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