Discovery, structure-activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity.

Takashi Yamamoto,Seiji Niwa,Satoshi Iwayama,Hajime Koganei,Shin-ichi Fujita,Tomoko Takeda,Morikazu Kito,Yukitsugu Ono,Yuki Saitou,Akira Takahara,Seinosuke Iwata,Hiroshi Yamamoto,Masataka Shoji

Bioorganic & Medicinal Chemistry（2006）

引用 34|浏览12

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摘要

The synthesis, structure–activity relationship study, and biological testings of novel series of cyproheptadine derivatives with N-type calcium channel inhibitory activity were described.

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关键词

N-type calcium channel,Analgesic activity,Structure–activity relationship study,Cyproheptadine

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