Novel factor Xa inhibitors based on a benzoic acid scaffold and incorporating a neutral P1 ligand.

Marc Nazaré,Hans Matter,Otmar Klingler,Fahad Al-Obeidi,Herman Schreuder,Gerhard Zoller,Jörg Czech,Martin Lorenz,Angela Dudda,Anusch Peyman,Hans Peter Nestler,Matthias Urmann,Armin Bauer,Volker Laux,Volkmar Wehner,David W Will

Bioorganic & Medicinal Chemistry Letters（2004）

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摘要

A series of novel, highly potent, achiral factor Xa inhibitors based on a benzoic acid scaffold and containing a chlorophenethyl moiety directed towards the protease S1 pocket is described. The compound shown was found to be the most active in a number of antithrombotic assays.

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Factor Xa inhibitor

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