Expression and Significance of Prosaposin (PSAP) in A Rat Model of Letrozole-induced Polycystic Ovary Syndrome

Objective To investigate the prosaposin (PSAP) expression in polycystic ovaries. Methods The expression of PSAP was examined using immunohistochemistry, quantitative RT-PCR and Western blotting in a rat model with letrozole-induced polycystic ovary syndrom (PCOS). Results Letrozole-induced PCOS rat models were similar to those in human PCOS in endocrine disturbances, metabolic characteristics and morphology features. And in these models both mRNA and protein levels of PSAP were significantly increased. Conclusion PSAP was overexpressed in the letrozole-induced PCOS rat model and might play an important role in the occurance and development of PCOS.