An Automated Determination of Urinary 4-Hydroxy-3-methoxymandelic Acid

An automated method for the determination of urinary 4-hydroxy-3-methoxy-mandelic acid is described. It is based on the procedure of Pisano et al (Clin Chim Acta, 1962; 7: 285–291). The correlation between the automated method and HPLC was high even though diet and medications were not restricted. The method has the advantages of short analysis time, specificity, and precision.