Asymmetric Total Syntheses of (+)-Coronafacic Acid and (+)-Coronatine.

An asymmetric total synthesis of (+)-coronafacic acid, starting from (R)-(+)-3-acetoxy-2-cyclopen-1-one as a chiral source, was accomplished, Construction of the 1-hydrindanone framework was carried out by using intramolecular 1,6-conjugate addition as the key step, Coupling between (+)-coronafacic acid and protected coronamic acid, and subsequent deprotection provided (+)-coronatine, This is the first asymmetric total synthesis of (+)-coronatine.